The Asus Transformer Prime pioneer users, who just got their machines recently, are reportedly coming across one of these problems that often arise with the first devices of a given chipset, despite all the QA testing companies do. The first quad-core tablet, powered by NVIDIA's Tegra 3 silicon, seemingly has issues with its GPS signal lock and tracking.
Granted, it is an aluminum-clad slate, which usually stands in the way of receiving signals from the proverbial ether, but the fact that Asus removed the GPS listing from the Transformer Prime's specs doesn't bode well for a simple or quick resolution of the matter. Here is the official company comment sent to a user, who probed them about the GPS conundrum.
There is a whole XDA thread created about the problem, and Asus reps have apparently also suggested things like first locking your position while in a Wi-Fi range, but some users are reporting locking up to 9 satellites and still not being able to get tracked, so there could be deeper issues at play here.