This includes not only the default apps like the Calendar that fits more events now, or Mail, Keynote, Page, Numbers, Garage Band and so on, but also third party applications.
Some devs have been given early access to the screen's size and specs, so they have totally reworked their apps to fit the new display. Apple's Phil Schiller gave example with CNN and Open Table, whose app interface is now more spaced out indeed, and fitting more info on one screen.
As for the other, unoptimized apps - "Well here's an app that hasn't been updated. It runs at the same size. We center it and place black borders on either side," said Phil Schiller.