ISIS is PIN protected and if you lose your phone, any of the three carriers will protect your accounts in the blink of an eye. The service will currently work with certain credit cards issued by American Express and Chase along with some loyalty cards belonging to specific retailers. And keep in mind that not every handset sold by Verizon, AT&T and T-Mobile will work with ISIS. To find out which models will work on each of the three carriers, click on the appropriate link below.
Once you've confirmed that your phone is enabled with ISIS, you install an enhanced SIM card on your phone, and go into the Google Play Store and download the appropriate ISIS app. Once that is done, you enter the acceptable credit cards into your wallet and you're ready to go.
source: ISIS (Verizon|AT&T|T-Mobile)